With an aim of reviewing the application of Eupatorium plants as a potential cosmetic agent, this article explores pharmacological effects of Eupatorium, including antifungal, antibacterial, cytotoxic, and antinociceptive properties. In terms of cosmetic applications, the activities of Eupathorium were found to be antioxidant, anti-tyrosinase, anti-melanin/melanogenesis, anti-acne, and anti-inflammatory.