While investigating the in vitro photoprotective efficacy and photostability of lipstick formulations containing titanium dioxide (TiO2) incorporated into mesoporous silica (SBA-15), researchers used samples with SBA-15; TiO2 (free form); and TiO2 incorporated into SBA-15 as lipstick base. The photoprotective efficacy was characterized in vitro. Lipsticks were irradiated in a Suntest CPS+ chamber to evaluate functional photostability. Lipstick base and SBA-15 alone did not display photoprotective efficacy. The sample containing 10.0% TiO2 incorporated into the mesoporous silica generated greater photostability and sun protection factor (SPF) value compared to the one containing only 10.0% TiO2 (free state). Findings suggested that TiO2 + SBA-15 can be considered a broad-spectrum ingredient for innovative sunscreens, particularly for the photoprotection of the lips.