Involvement of Aquaporin 1 in the Motility and in the Production of Fibrillin 1 and Type I Collagen of Cultured Human Dermal Fibroblasts

In this study, researchers clarified the involvement of  aquaporin 1 (AQP1) in collagen gel contraction and the production of fibrillin 1 and type I collagen in cultured human dermal fibroblasts. Their findings suggest that AQP1 is an important biomolecule for cell motility in human dermal fibroblasts and that decreased motility results in decreased expression of extracellular matrix proteins such as fibrillin 1 and type I collagen.